Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function
نویسندگان
چکیده
منابع مشابه
Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function.
The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders. No change in function (loss or gain) has been described for this SNP so far. Here we show that although the P2X7R-Gln460Arg variant ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0151862